Detalhe da pesquisa
1.
In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Nature
; 561(7723): 416-419, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209390
2.
Allostatic hypermetabolic response in PGC1α/ß heterozygote mouse despite mitochondrial defects.
FASEB J
; 35(9): e21752, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34369602
3.
Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice.
Neuroendocrinology
; 112(3): 215-234, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-33774644
4.
GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens.
Immunol Cell Biol
; 99(2): 234-243, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32888232
5.
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.
Clin Sci (Lond)
; 135(20): 2393-2408, 2021 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34622923
6.
PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD.
Liver Int
; 41(2): 321-332, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33091218
7.
Mitochondria are required for pro-ageing features of the senescent phenotype.
EMBO J
; 35(7): 724-42, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26848154
8.
CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.
Stem Cells
; 37(7): 958-972, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30932271
9.
Decoding non-random mutational signatures at Cas9 targeted sites.
Nucleic Acids Res
; 46(16): 8417-8434, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30032200
10.
In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.
BMC Biol
; 17(1): 4, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30646909
11.
Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.
Mol Genet Metab
; 126(4): 377-387, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803894
12.
Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice.
J Card Fail
; 24(7): 470-478, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29802896
13.
Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.
Am J Physiol Endocrinol Metab
; 313(1): E48-E62, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28325731
14.
Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.
Toxicol Pathol
; 44(3): 346-57, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26511847
15.
Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1.
Circulation
; 127(2): 233-43, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23204105
16.
Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
Nat Commun
; 15(1): 2315, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38485951
17.
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling.
Diabetes
; 72(10): 1350-1363, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580483
18.
A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo.
Nat Commun
; 14(1): 5474, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37673883
19.
Simultaneous inhibition of DNA-PK and PolÏ´ improves integration efficiency and precision of genome editing.
Nat Commun
; 14(1): 4761, 2023 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37580318
20.
Over-expression of Adamts1 in mice alters bone mineral density.
J Bone Miner Metab
; 30(3): 304-11, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22002813